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Journal of Current Science and Technology

ISSN 2630-0656 (Online)

Sickle-cell disease: a review of oral manifestation and presentation of a case with an uncommon complication of the disease

  • Ozgur Erdogan, Faculty of Dentistry, Rangsit University, Patum Thani, Thailand , Corresponding author; E-mail:
  • Halil Ibrahim Kisa, Faculty of Dentistry, Cukurova University, Adana, Turkey
  • Sureeporn Charudilaka, Private Practice, Bangkok, Thailand


          Sickle-cell disease (SCD) is a genetic hematological disease, in which polymerization of abnormal hemoglobin leads to morphologic alteration in erythrocytes.  It is characterized with several systemic and local manifestations.  An unusual complication of SCD is the mental nerve paraesthesia, which is associated with acute phase of the disease.  The aim of this article is to review the general clinical and radiographic findings of the disease and to present a SCD patient with bilateral mental nerve paraesthesia.

Keywords: sickle-cell disease; oral complications; paraesthesia; case report

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DOI: 10.14456/rjas.2013.5


Anil, A., Peker, T., Turgut, H. B., Gülekon, I. N., & Liman, F. (2003). Variations in the anatomy of the inferior alveolar nerve. Br J Oral Maxillofac Surg, 41(4), 236-239.

Beutler, E. (1998). Hemoglobinopathies. In T.R.Harrison & A. S. Fauci (Eds), Harrison's principles of internal medicine, 14th ed., (pp. 645-652). New York, USA: The McGraw-Hill Companies, Inc.

Boehm, C. D., Antonarakis, S. E., Phillips, J. A. 3rd, Stetten, G., & Kazazian, H. H. Jr. (1983). Prenatal diagnosis using DNA polymorphisms. Report on 95 pregnancies at risk for sickle-cell disease or beta-thalassemia. N Engl J Med, 308(18), 1054-1058.

Cooper, R. A., & Bunn, H. F. (1977). Hemolytic anemias and hemoglobinopathies In G. W. Thorn, R. D. Adams, E. Braunwald, K. J. Isselbacher, & R. G. Petersdorf (Eds), Harrison's principles of internal medicine, 8th ed., (pp1674-1688). New York, USA: The McGraw-Hill Companies, Inc.

da Fonseca, M., Oueis, H. S., & Casamassimo, P. S. (2007). Sickle cell anemia: a review for the pediatric dentist. Pediatr Dent, 29(2), 159-169.

Friedlander, A. H., Genser, L., & Swerdloff, M. (1980). Mental nerve neuropathy: a complication of sickle-cell crisis. Oral Surg Oral Med Oral Pathol, 49, 15-17.

Hamdoun, E., Davis, L., McCrary, J. S., Eklund, N. V., & Evans, O. B. (2012). Bilateral mental nerve neuropaty in an adolescent during sickle cell crises. J Child Neurol, 27(8), 1038-1041.

Kirson, L. E., & Tomaro, A. J. (1979). Mental nerve paresthesia secondary to sickle cell crisis. Oral Surg Oral Med Oral Pathol, 48(6), 509-512.

Konotey-Ahulu, F. I. (1972). Mental-nerve neuropathy: a complication of sickle cell crisis. Lancet, 2(7773), 388.

Laurencet, F. M., Anchisi, S., Tullen, E., & Dietrich, P. Y. (2000). Report of five cases and rewiew of the literature. Crit Rev Oncol Hematol, 34(1), 71-79.

Licciardello, V., Bertuna, G., & Samperi, P. (2007). Craniofacial morphology in patients with sickle cell disease: a cephalometric analysis. Eur J Orthod., 29(3), 238-242.

Maia, N. G., dos Santos, L. A., Coletta, R. D., Mendes, P. H., Bonan, P. R., Maia, L .B., & Junior, M. H. (2011). Facial features of patients with sickle cell anemia. Angle Orthod., 81(1), 115-120. doi:

McFarlane, J. (1977). Sickle Cell Disorders. Am J Nurs, 77(12), 1948-1954. PMID: 244260 [PubMed - indexed for MEDLINE]

Mendes, P. H. C., Fonseca, N. G., Martelli, D. R. B., Bonan, P. R. F., de Almeida, L. K. Y., de Melo, L. A., & Junior, H. M. (2011). Orofacial manifestations in patients with sickle cell anemia. Quintessence Int, 42(8), 701-709.

Neves, F. S., Passos, C. P., Oliveira-Santos, C., Cangussu, M. C., Campos, P. S., Nascimento, R. J., Crusoé-Rebello, I., & Campos, M. I. (2012). Correlation between maxillofacial radiographic features and systemic severity as sickle cell disease severity predictor. Clin Oral Investig, 16(3), 827-833. DOI: 10.1007/s00784-011-0577-0

Okpala, I. (2004). The intriguing contribution of white blood cells to sickle cell disease - a red cell disorder. Blood Rev, 18(1), 65-73.

Platt, O. S., Brambilla, D. J., Rosse, W. F., Milner, P. F., Castro, O., Steinberg, M. H., & Klug, P. P. (1994). Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med, 330(23), 1639-1644.

Rees, D. C., Williams, T., N., & Gladwin, M. T. (2010). Sickle-cell disease. Lancet, 376(9757), 2018-2031.

Seeler, R. A., & Royal, J. E. (1982). Mental nerve neuropathy in a child with sickle cell anemia. The American Journal of Pediatric Hematology/Oncology, 4, 213-213.

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