ISSN 2630-0583 (Print)

ISSN 2630-0656 (Online)

JCST

Journal of Current Science and Technology

http://jcst.rsu.ac.th

Rangsit Journal of Arts and Sciences. Vol.2 No.2 , July - December 2012.

Targeting reactive oxygen species to overcome cisplatin resistance in lung cancer.

Medhi Wangpaichitr, George Theodoropoulos, and Niramol Savaraj

Abstract

           Cisplatin resistance remains a major problem in the treatment of both small cell and non small cell lung cancer (NSCLC).  We have discovered that cisplatin resistant (CR) cells share one common biochemical parameter, increased reactive oxygen species (ROS), when compared to normal cells and  their parental cells counterparts.  Treating CR cells with either a ROS inducing agent (elesclomol), or an antioxidant agent (N-acetylcysteine) resulted in a significant growth inhibitory effect.  This suggested that ROS levels were an important component in the survival of these cells.  Co-treatment of cisplatin with NAC however resulted in and antagonistic effect, while elesclomol in combination with cisplatin treatment enhanced cisplatin sensitivity in CR cells.  Our findings suggest a novel approach to overcome CR in lung tumors. Combining a ROS inducing agent with cisplatin may prove to be clinically efficacious.

Keywords: lung cancer, cisplatin resistance, reactive oxygen species

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