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JCST

Journal of Current Science and Technology

ISSN 2630-0656 (Online)

Perspective on the treatment of non-small cell lung cancer in the context of potential SARS-CoV-2 infection during the pandemic

  • George Theodoropoulos, Department of Veterans Affairs, Miami VA Healthcare System, Research Service, Miami, FL
  • Katerina Albanis, Department of Veterans Affairs, Miami VA Healthcare System, Research Service, Miami, FL
  • Medhi Wangpaichitr, Department of Veterans Affairs, Miami VA Healthcare System, Research Service, Miami, FL & Department of Surgery, Cardiothoracic Surgery, Miller School of Medicine, University of Miami, Miami,, Corresponding Author; E-mail: mwangpaichitr@med.miami.edu

Abstract

SARS-CoV-2 infections are rising at an alarming rate and various aspects of this pandemic must be quickly and adequately addressed in order to enhance effective healthcare delivery and protect at risk populations such as cancer patients.  Preventing Covid-19 infection must be a top system wide priority to avoid mortality, and considerable financial and disease burden.  Most cancer patients, and in particular those with tumors resistant to chemotherapy are particularly vulnerable to infection.  In this review, we connect potential viral infection of patients with lung tumors that have somewhat quiesced the immune response in the tumor microenvironment and categorize target molecules in metabolism that may be used to identify at risk patients leading to more effective treatment regimens; keeping continuity of therapy and disease prevention during a very tumultuous period of time surrounding the pandemic.

Keywords: immunosuppressive; infection; lung cancer; metabolism; SARS-CoV-2; treatment; tumor microenvironment

PDF (354.76 KB)

DOI: 10.14456/jcst.2021.15

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